Run Data Run
SubstackBuilding in public. AI experiments, lessons learned, and the journey of treating AI as a multiplier.
The Year Nature Caught Up
Robin found a new use for an old glaucoma drug and landed in Nature. The preprint was fourteen months old. Once you notice that lag, you notice it everywhere.
How I Actually Stay Current on AI (I Built a Wire)
The question I get asked most, and the system that answers it.
AI Ate the Keyboard. Now It Has to Eat the Queue.
Software stopped being the limiting factor. Process didn't. In biopharma and any patient-facing industry, the queue is the patient.
Every AI Book Tells You What to Think. This One Is About What Your Hands Do.
There is a whole shelf of AI books for leaders now. I read enough of them to know why I wrote a different kind.
The Gap, and the Book That Came Out of It
There's a line splitting the AI conversation that nobody's arguing about, because most people don't know it's there. I've spent months on the wrong-versus-right side of it. The book is out now.
Claude Science and the boring 80 percent
Anthropic shipped a workbench, not a miracle. The model is the commodity layer. The harness around it is the moat.
Earlier posts (13 more)
Borrowed Iron
A borrowed eight-GPU node, a global-health mission, and a crew of six: me, a founder, and four interns.
The Harness Is the Moat
The model is the part of your AI strategy you can order off a price sheet. The thing you build around it is the part nobody can copy. I made mine public so you can see the shape of it.
Ep. 1: Two Groups
Same AI, same task, a different result. The difference isn't the model.
What AI Didn't Reprice
AI marked down almost every skill on your team this year. One it marked up. If you run a budget, that one number should change where you're spending.
You Don't Have to Write the Code
Anthropic watched 400,000 sessions with a coding agent and found that what predicts success isn't your job or your syntax. It's whether you understand the work. That changes who gets to build, and...
The Wrong Tool Problem in Genomic AI
A leaderboard tells you which model wins. It can't tell you that you picked the wrong kind of model.
What one day with Fable 5 looks like for a builder
Most private tools that work never become public ones. Here's the afternoon that gap collapsed.
Apple Rented Its Brain
The company that owns its whole stack just outsourced the one part you'd assume it never would. That choice is the most interesting thing at WWDC.
AI Is Building AI. Now Read the Footnotes.
Anthropic published striking evidence that AI is automating its own development. The shift is happening. The way it was sold deserves a closer look.
She Already Built It
I set out to add federated learning to my research agent. She'd already designed and built it in February. This is what compounding autonomous research actually looks like.
The skill that edits its own instructions
Self-editing skills, the ecosystem racing to build them, and the flywheel that makes any of it compound.
Pulling Threads
I dropped my autonomous loop into a blind pharma challenge with zero background in the field. Then I read my own write-up and noticed I kept saying "I".
Opus 4.8 and Workflows - One Careful Pass Is No Longer the Default
Anthropic shipped Opus 4.8 and Dynamic Workflows on the same day. Together they move the unit of agentic work from one model call to dozens of verified ones.
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Subscribe on SubstackTechnical Deep Dives
In-depth technical articles from my AI research garden. Reference material on architectures, implementations, and emerging patterns.
The Five Leadership Primitives Already Transfer
Technical article
Inventory Your Harness: The Six Components
Technical article
Maximizing Toward The Local Minimum: How Fast Optimization Drifts, And The Human Habit That Catches It
Technical article
Why Your Org Can&Apos;T Cross (Run Your Own Pilot Numbers)
Technical article
Hear The Three Tiers (And Name The Failure Mode)
Technical article
Which Side Of The Build Gap Are You On? (Run The Scorecard)
Technical article