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Run Data Run

Substack

Building in public. AI experiments, lessons learned, and the journey of treating AI as a multiplier.

Earlier posts (13 more)
The Genesis Simulation: A Memo from 2035
Nov 27, 2025

The Genesis Simulation: A Memo from 2035

Looking back at the moment Science and AI merged—and the prompt that saved us.

The Death of the Blank Canvas
Nov 22, 2025

The Death of the Blank Canvas

How Gemini and Claude Are Rewriting the Rules

Decoding AI in Cancer Research
Nov 14, 2025

Decoding AI in Cancer Research

A Practical Guide to Interpretability and What’s Next

The Future of Scientific Computing
Nov 6, 2025

The Future of Scientific Computing

Part 3 of 3: Nine Days of Petaflop Delegation

Compound Velocity: The 20-Hour AI Research Lab
Nov 4, 2025

Compound Velocity: The 20-Hour AI Research Lab

Part 2 of 3: Nine Days of Petaflop Delegation - Building monitoring while fine-tuning while training while documenting while...

Delegation, Not Automation: How Human-AI Collaboration Actually Works
Nov 3, 2025

Delegation, Not Automation: How Human-AI Collaboration Actually Works

Part 1 of 3: Nine Days of Petaflop Delegation

From Petaflop to Production: Building a RAG Research Platform on the DGX in One Afternoon
Oct 27, 2025

From Petaflop to Production: Building a RAG Research Platform on the DGX in One Afternoon

Last week, I wrote about getting my NVIDIA DGX Spark up and running in three days.

Three Days, One Petaflop, and an AI Partner: Building a Research Lab
Oct 22, 2025

Three Days, One Petaflop, and an AI Partner: Building a Research Lab

Building a GPU research lab with Claude Code, and documenting both what I built and how we built it

The Quiet Week Claude Became Your Coworker
Oct 20, 2025

The Quiet Week Claude Became Your Coworker

Skills, Agents, and the Infrastructure Nobody Noticed

When the AI Picked a Drug Nobody Was Testing
Oct 16, 2025

When the AI Picked a Drug Nobody Was Testing

How teaching an AI to read cells as text revealed a context-dependent cancer mechanism

From Workslop to Agentic Slop
Oct 10, 2025

From Workslop to Agentic Slop

How AI Agents Could Make a Bad Problem Worse

The $2B Bet on the 90/90 Rule - Thinking Machines and Tinker
Oct 6, 2025

The $2B Bet on the 90/90 Rule - Thinking Machines and Tinker

Why Fine-Tuning Infrastructure Matters More Than You Think

Cancer AI Alliance: When Federated Learning Finally Works
Oct 2, 2025

Cancer AI Alliance: When Federated Learning Finally Works

Four cancer centers did in 12 months what the industry couldn't do in 10 years. Here's what actually changed.

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